山东省脑瘤：（回顾，这应该是PCNSL治疗中最有意义的一个临床研究，它奠定了单纯化疗的基础）
RandomizedphaseIIIstudyofwhole-brainradiotherapyforprimaryCNSlymphoma.
作者及单位：FromtheDepartmentofHematology,OncologyandTumorImmunology(A.K.,E.T.,L.F.,K.J.),ChariteBerlin;theDepartmentsofClinicalEpidemiologyandAppliedBiostatistics(P.M.)andHematologyandOncology(R.M.),UniversityTubingen;theDepartmentofRadiotherapyandMedicalOncology(F.G.),PiusHospitalOldenburg;theDepartmentofNeurology(M.R.),ProtestantHospitalBielefeld;theDepartmentofHematology(A.R.),UniversityHospitalEssen;theDepartmentofInternalMedicine(B.H.),HospitalBremenCenter;theDepartmentofHematologyandOncology(T.F.),UniversityHospitalMagdeburg;theDepartmentofNeurology(T.H.),UniversityHospitalMainz;theDepartmentofHematologyandOncology(H.G.M.),KlinikumStuttgart;theDepartmentofHematologyandOncology(C.J.),UniversityHospitalRostock;theDepartmentofNeurology(T.B.),UniversityHospitalMunichLMU;theDepartmentsofNeurology(U.H.,P.R.,M.W.)andRadiationOncology(M.B.),UniversityHospitalTubingen;theDepartmentofNeurology(U.H.),UniversityBonn,Germany;theDepartmentofNeurology(P.R.,M.W.),UniversityHospitalZurich,Switzerland;andtheInstituteofNeuropathology(T.P.),UniversityHospitalBonn,Germany.agnieszka.korfel
charite.de.;FromtheDepartmentofHematology,OncologyandTumorImmunology(A.K.,E.T.,L.F.,K.J.),ChariteBerlin;theDepartmentsofClinicalEpidemiologyandAppliedBiostatistics(P.M.)andHematologyandOncology(R.M.),UniversityTubingen;theDepartmentofRadiotherapyandMedicalOncology(F.G.),PiusHospitalOldenburg;theDepartmentofNeurology(M.R.),ProtestantHospitalBielefeld;theDepartmentofHematology(A.R.),UniversityHospitalEssen;theDepartmentofInternalMedicine(B.H.),HospitalBremenCenter;theDepartmentofHematologyandOncology(T.F.),UniversityHospitalMagdeburg;theDepartmentofNeurology(T.H.),UniversityHospitalMainz;theDepartmentofHematologyandOncology(H.G.M.),KlinikumStuttgart;theDepartmentofHematologyandOncology(C.J.),UniversityHospitalRostock;theDepartmentofNeurology(T.B.),UniversityHospitalMunichLMU;theDepartmentsofNeurology(U.H.,P.R.,M.W.)andRadiationOncology(M.B.),UniversityHospitalTubingen;theDepartmentofNeurology(U.H.),UniversityBonn,Germany;theDepartmentofNeurology(P.R.,M.W.),UniversityHospitalZurich,Switzerland;andtheInstituteofNeuropathology(T.P.),UniversityHospitalBonn,Germany.;FromtheDepartmentofHematology,OncologyandTumorImmunology(A.K.,E.T.,L.F.,K.J.),ChariteBerlin;theDepartmentsofClinicalEpidemiologyandAppliedBiostatistics(P.M.)andHematologyandOncology(R.M.),UniversityTubingen;theDepartmentofRadiotherapyandMedicalOncology(F.G.),PiusHospitalOldenburg;theDepartmentofNeurology(M.R.),ProtestantHospitalBielefeld;theDepartmentofHematology(A.R.),UniversityHospitalEssen;theDepartmentofInternalMedicine(B.H.),HospitalBremenCenter;theDepartmentofHematologyandOncology(T.F.),UniversityHospitalMagdeburg;theDepartmentofNeurology(T.H.),UniversityHospitalMainz;theDepartmentofHematologyandOncology(H.G.M.),KlinikumStuttgart;theDepartmentofHematologyandOncology(C.J.),UniversityHospitalRostock;theDepartmentofNeurology(T.B.),UniversityHospitalMunichLMU;theDepartmentsofNeurology(U.H.,P.R.,M.W.)andRadiationOncology(M.B.),UniversityHospitalTubingen;theDepartmentofNeurology(U.H.),UniversityBonn,Germany;theDepartmentofNeurology(P.R.,M.W.),UniversityHospitalZurich,Switzerland;andtheInstituteofNeuropathology(T.P.),UniversityHospitalBonn,Germany.;FromtheDepartmentofHematology,OncologyandTumorImmunology(A.K.,E.T.,L.F.,K.J.),ChariteBerlin;theDepartmentsofClinicalEpidemiologyandAppliedBiostatistics(P.M.)andHematologyandOncology(R.M.),UniversityTubingen;theDepartmentofRadiotherapyandMedicalOncology(F.G.),PiusHospitalOldenburg;theDepartmentofNeurology(M.R.),ProtestantHospitalBielefeld;theDepartmentofHematology(A.R.),UniversityHospitalEssen;theDepartmentofInternalMedicine(B.H.),HospitalBremenCenter;theDepartmentofHematologyandOncology(T.F.),UniversityHospitalMagdeburg;theDepartmentofNeurology(T.H.),UniversityHospitalMainz;theDepartmentofHematologyandOncology(H.G.M.),KlinikumStuttgart;theDepartmentofHematologyandOncology(C.J.),UniversityHospitalRostock;theDepartmentofNeurology(T.B.),UniversityHospitalMunichLMU;theDepartmentsofNeurology(U.H.,P.R.,M.W.)andRadiationOncology(M.B.),UniversityHospitalTubingen;theDepartmentofNeurology(U.H.),UniversityBonn,Germany;theDepartmentofNeurology(P.R.,M.W.),UniversityHospitalZurich,Switzerland;andtheInstituteofNeuropathology(T.P.),UniversityHospitalBonn,Germany.;FromtheDepartmentofHematology,OncologyandTumorImmunology(A.K.,E.T.,L.F.,K.J.),ChariteBerlin;theDepartmentsofClinicalEpidemiologyandAppliedBiostatistics(P.M.)andHematologyandOncology(R.M.),UniversityTubingen;theDepartmentofRadiotherapyandMedicalOncology(F.G.),PiusHospitalOldenburg;theDepartmentofNeurology(M.R.),ProtestantHospitalBielefeld;theDepartmentofHematology(A.R.),UniversityHospitalEssen;theDepartmentofInternalMedicine(B.H.),HospitalBremenCenter;theDepartmentofHematologyandOncology(T.F.),UniversityHospitalMagdeburg;theDepartmentofNeurology(T.H.),UniversityHospitalMainz;theDepartmentofHematologyandOncology(H.G.M.),KlinikumStuttgart;theDepartmentofHematologyandOncology(C.J.),UniversityHospitalRostock;theDepartmentofNeurology(T.B.),UniversityHospitalMunichLMU;theDepartmentsofNeurology(U.H.,P.R.,M.W.)andRadiationOncology(M.B.),UniversityHospitalTubingen;theDepartmentofNeurology(U.H.),UniversityBonn,Germany;theDepartmentofNeurology(P.R.,M.W.),UniversityHospitalZurich,Switzerland;andtheInstituteofNeuropathology(T.P.),UniversityHospitalBonn,Germany.;FromtheDepartmentofHematology,OncologyandTumorImmunology(A.K.,E.T.,L.F.,K.J.),ChariteBerlin;theDepartmentsofClinicalEpidemiologyandAppliedBiostatistics(P.M.)andHematologyandOncology(R.M.),UniversityTubingen;theDepartmentofRadiotherapyandMedicalOncology(F.G.),PiusHospitalOldenburg;theDepartmentofNeurology(M.R.),ProtestantHospitalBielefeld;theDepartmentofHematology(A.R.),UniversityHospitalEssen;theDepartmentofInternalMedicine(B.H.),HospitalBremenCenter;theDepartmentofHematologyandOncology(T.F.),UniversityHospitalMagdeburg;theDepartmentofNeurology(T.H.),UniversityHospitalMainz;theDepartmentofHematologyandOncology(H.G.M.),KlinikumStuttgart;theDepartmentofHematologyandOncology(C.J.),UniversityHospitalRostock;theDepartmentofNeurology(T.B.),UniversityHospitalMunichLMU;theDepartmentsofNeurology(U.H.,P.R.,M.W.)andRadiationOncology(M.B.),UniversityHospitalTubingen;theDepartmentofNeurology(U.H.),UniversityBonn,Germany;theDepartmentofNeurology(P.R.,M.W.),UniversityHospitalZurich,Switzerland;andtheInstituteofNeuropathology(T.P.),UniversityHospitalBonn,Germany.;FromtheDepartmentofHematology,OncologyandTumorImmunology(A.K.,E.T.,L.F.,K.J.),ChariteBerlin;theDepartmentsofClinicalEpidemiologyandAppliedBiostatistics(P.M.)andHematologyandOncology(R.M.),UniversityTubingen;theDepartmentofRadiotherapyandMedicalOncology(F.G.),PiusHospitalOldenburg;theDepartmentofNeurology(M.R.),ProtestantHospitalBielefeld;theDepartmentofHematology(A.R.),UniversityHospitalEssen;theDepartmentofInternalMedicine(B.H.),HospitalBremenCenter;theDepartmentofHematologyandOncology(T.F.),UniversityHospitalMagdeburg;theDepartmentofNeurology(T.H.),UniversityHospitalMainz;theDepartmentofHematologyandOncology(H.G.M.),KlinikumStuttgart;theDepartmentofHematologyandOncology(C.J.),UniversityHospitalRostock;theDepartmentofNeurology(T.B.),UniversityHospitalMunichLMU;theDepartmentsofNeurology(U.H.,P.R.,M.W.)andRadiationOncology(M.B.),UniversityHospitalTubingen;theDepartmentofNeurology(U.H.),UniversityBonn,Germany;theDepartmentofNeurology(P.R.,M.W.),UniversityHospitalZurich,Switzerland;andtheInstituteofNeuropathology(T.P.),UniversityHospitalBonn,Germany.;FromtheDepartmentofHematology,OncologyandTumorImmunology(A.K.,E.T.,L.F.,K.J.),ChariteBerlin;theDepartmentsofClinicalEpidemiologyandAppliedBiostatistics(P.M.)andHematologyandOncology(R.M.),UniversityTubingen;theDepartmentofRadiotherapyandMedicalOncology(F.G.),PiusHospitalOldenburg;theDepartmentofNeurology(M.R.),ProtestantHospitalBielefeld;theDepartmentofHematology(A.R.),UniversityHospitalEssen;theDepartmentofInternalMedicine(B.H.),HospitalBremenCenter;theDepartmentofHematologyandOncology(T.F.),UniversityHospitalMagdeburg;theDepartmentofNeurology(T.H.),UniversityHospitalMainz;theDepartmentofHematologyandOncology(H.G.M.),KlinikumStuttgart;theDepartmentofHematologyandOncology(C.J.),UniversityHospitalRostock;theDepartmentofNeurology(T.B.),UniversityHospitalMunichLMU;theDepartmentsofNeurology(U.H.,P.R.,M.W.)andRadiationOncology(M.B.),UniversityHospitalTubingen;theDepartmentofNeurology(U.H.),UniversityBonn,Germany;theDepartmentofNeurology(P.R.,M.W.),UniversityHospitalZurich,Switzerland;andtheInstituteofNeuropathology(T.P.),UniversityHospitalBonn,Germany.;FromtheDepartmentofHematology,OncologyandTumorImmunology(A.K.,E.T.,L.F.,K.J.),ChariteBerlin;theDepartmentsofClinicalEpidemiologyandAppliedBiostatistics(P.M.)andHematologyandOncology(R.M.),UniversityTubingen;theDepartmentofRadiotherapyandMedicalOncology(F.G.),PiusHospitalOldenburg;theDepartmentofNeurology(M.R.),ProtestantHospitalBielefeld;theDepartmentofHematology(A.R.),UniversityHospitalEssen;theDepartmentofInternalMedicine(B.H.),HospitalBremenCenter;theDepartmentofHematologyandOncology(T.F.),UniversityHospitalMagdeburg;theDepartmentofNeurology(T.H.),UniversityHospitalMainz;theDepartmentofHematologyandOncology(H.G.M.),KlinikumStuttgart;theDepartmentofHematologyandOncology(C.J.),UniversityHospitalRostock;theDepartmentofNeurology(T.B.),UniversityHospitalMunichLMU;theDepartmentsofNeurology(U.H.,P.R.,M.W.)andRadiationOncology(M.B.),UniversityHospitalTubingen;theDepartmentofNeurology(U.H.),UniversityBonn,Germany;theDepartmentofNeurology(P.R.,M.W.),UniversityHospitalZurich,Switzerland;andtheInstituteofNeuropathology(T.P.),UniversityHospitalBonn,Germany.;FromtheDepartmentofHematology,OncologyandTumorImmunology(A.K.,E.T.,L.F.,K.J.),ChariteBerlin;theDepartmentsofClinicalEpidemiologyandAppliedBiostatistics(P.M.)andHematologyandOncology(R.M.),UniversityTubingen;theDepartmentofRadiotherapyandMedicalOncology(F.G.),PiusHospitalOldenburg;theDepartmentofNeurology(M.R.),ProtestantHospitalBielefeld;theDepartmentofHematology(A.R.),UniversityHospitalEssen;theDepartmentofInternalMedicine(B.H.),HospitalBremenCenter;theDepartmentofHematologyandOncology(T.F.),UniversityHospitalMagdeburg;theDepartmentofNeurology(T.H.),UniversityHospitalMainz;theDepartmentofHematologyandOncology(H.G.M.),KlinikumStuttgart;theDepartmentofHematologyandOncology(C.J.),UniversityHospitalRostock;theDepartmentofNeurology(T.B.),UniversityHospitalMunichLMU;theDepartmentsofNeurology(U.H.,P.R.,M.W.)andRadiationOncology(M.B.),UniversityHospitalTubingen;theDepartmentofNeurology(U.H.),UniversityBonn,Germany;theDepartmentofNeurology(P.R.,M.W.),UniversityHospitalZurich,Switzerland;andtheInstituteofNeuropathology(T.P.),UniversityHospitalBonn,Germany.;FromtheDepartmentofHematology,OncologyandTumorImmunology(A.K.,E.T.,L.F.,K.J.),ChariteBerlin;theDepartmentsofClinicalEpidemiologyandAppliedBiostatistics(P.M.)andHematologyandOncology(R.M.),UniversityTubingen;theDepartmentofRadiotherapyandMedicalOncology(F.G.),PiusHospitalOldenburg;theDepartmentofNeurology(M.R.),ProtestantHospitalBielefeld;theDepartmentofHematology(A.R.),UniversityHospitalEssen;theDepartmentofInternalMedicine(B.H.),HospitalBremenCenter;theDepartmentofHematologyandOncology(T.F.),UniversityHospitalMagdeburg;theDepartmentofNeurology(T.H.),UniversityHospitalMainz;theDepartmentofHematologyandOncology(H.G.M.),KlinikumStuttgart;theDepartmentofHematologyandOncology(C.J.),UniversityHospitalRostock;theDepartmentofNeurology(T.B.),UniversityHospitalMunichLMU;theDepartmentsofNeurology(U.H.,P.R.,M.W.)andRadiationOncology(M.B.),UniversityHospitalTubingen;theDepartmentofNeurology(U.H.),UniversityBonn,Germany;theDepartmentofNeurology(P.R.,M.W.),UniversityHospitalZurich,Switzerland;andtheInstituteofNeuropathology(T.P.),UniversityHospitalBonn,Germany.;FromtheDepartmentofHematology,OncologyandTumorImmunology(A.K.,E.T.,L.F.,K.J.),ChariteBerlin;theDepartmentsofClinicalEpidemiologyandAppliedBiostatistics(P.M.)andHematologyandOncology(R.M.),UniversityTubingen;theDepartmentofRadiotherapyandMedicalOncology(F.G.),PiusHospitalOldenburg;theDepartmentofNeurology(M.R.),ProtestantHospitalBielefeld;theDepartmentofHematology(A.R.),UniversityHospitalEssen;theDepartmentofInternalMedicine(B.H.),HospitalBremenCenter;theDepartmentofHematologyandOncology(T.F.),UniversityHospitalMagdeburg;theDepartmentofNeurology(T.H.),UniversityHospitalMainz;theDepartmentofHematologyandOncology(H.G.M.),KlinikumStuttgart;theDepartmentofHematologyandOncology(C.J.),UniversityHospitalRostock;theDepartmentofNeurology(T.B.),UniversityHospitalMunichLMU;theDepartmentsofNeurology(U.H.,P.R.,M.W.)andRadiationOncology(M.B.),UniversityHospitalTubingen;theDepartmentofNeurology(U.H.),UniversityBonn,Germany;theDepartmentofNeurology(P.R.,M.W.),UniversityHospitalZurich,Switzerland;andtheInstituteofNeuropathology(T.P.),UniversityHospitalBonn,Germany.;FromtheDepartmentofHematology,OncologyandTumorImmunology(A.K.,E.T.,L.F.,K.J.),ChariteBerlin;theDepartmentsofClinicalEpidemiologyandAppliedBiostatistics(P.M.)andHematologyandOncology(R.M.),UniversityTubingen;theDepartmentofRadiotherapyandMedicalOncology(F.G.),PiusHospitalOldenburg;theDepartmentofNeurology(M.R.),ProtestantHospitalBielefeld;theDepartmentofHematology(A.R.),UniversityHospitalEssen;theDepartmentofInternalMedicine(B.H.),HospitalBremenCenter;theDepartmentofHematologyandOncology(T.F.),UniversityHospitalMagdeburg;theDepartmentofNeurology(T.H.),UniversityHospitalMainz;theDepartmentofHematologyandOncology(H.G.M.),KlinikumStuttgart;theDepartmentofHematologyandOncology(C.J.),UniversityHospitalRostock;theDepartmentofNeurology(T.B.),UniversityHospitalMunichLMU;theDepartmentsofNeurology(U.H.,P.R.,M.W.)andRadiationOncology(M.B.),UniversityHospitalTubingen;theDepartmentofNeurology(U.H.),UniversityBonn,Germany;theDepartmentofNeurology(P.R.,M.W.),UniversityHospitalZurich,Switzerland;andtheInstituteofNeuropathology(T.P.),UniversityHospitalBonn,Germany.;FromtheDepartmentofHematology,OncologyandTumorImmunology(A.K.,E.T.,L.F.,K.J.),ChariteBerlin;theDepartmentsofClinicalEpidemiologyandAppliedBiostatistics(P.M.)andHematologyandOncology(R.M.),UniversityTubingen;theDepartmentofRadiotherapyandMedicalOncology(F.G.),PiusHospitalOldenburg;theDepartmentofNeurology(M.R.),ProtestantHospitalBielefeld;theDepartmentofHematology(A.R.),UniversityHospitalEssen;theDepartmentofInternalMedicine(B.H.),HospitalBremenCenter;theDepartmentofHematologyandOncology(T.F.),UniversityHospitalMagdeburg;theDepartmentofNeurology(T.H.),UniversityHospitalMainz;theDepartmentofHematologyandOncology(H.G.M.),KlinikumStuttgart;theDepartmentofHematologyandOncology(C.J.),UniversityHospitalRostock;theDepartmentofNeurology(T.B.),UniversityHospitalMunichLMU;theDepartmentsofNeurology(U.H.,P.R.,M.W.)andRadiationOncology(M.B.),UniversityHospitalTubingen;theDepartmentofNeurology(U.H.),UniversityBonn,Germany;theDepartmentofNeurology(P.R.,M.W.),UniversityHospitalZurich,Switzerland;andtheInstituteofNeuropathology(T.P.),（由于本文字数限制尚有至少几十名作者不能一一列出）摘要：
OBJECTIVE:ThisisthefinalreportofaphaseIIIrandomizedstudytoevaluatewhole-brainradiotherapy(WBRT)inprimarytherapyofprimaryCNSlymphoma(PCNSL)afteramedianfollow-upof81.2months.METHODS:PatientswithnewlydiagnosedPCNSLwererandomizedtohigh-dosemethotrexate(HDMTX)-basedchemotherapyaloneorfollowedbyWBRT.WehypothesizedthattheomissionofWBRTwouldnot